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The Binding of Isaac: Rebirth — roguelike dungeon gameplay with Isaac fighting monsters

The Binding of Isaac: Rebirth Wiki

Your complete wiki for The Binding of Isaac: Rebirth — covering Repentance and Repentance+. Browse 719+ items, all 34 characters, boss strategies, progression guides, Dead God roadmaps, and interactive tools to master every run from Basement to The Beast.

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Items & Synergies

Master Isaac's massive item pool with pool breakdowns, quality tiers, and synergy guides.

All Items Guide Complete overview of every passive, active, and familiar item across all DLC. Item Pools Learn where items spawn and how devil, angel, and treasure pools interact. Quality Tier List Hidden quality ratings from 0–4 and how they affect reroll mechanics. Synergies Guide Best combos, dangerous anti-synergies, and transformation interactions.

Characters & Unlocks

Every character, Tainted variant, completion marks, and Birthright effects explained.

All Characters Stats, starting items, and playstyles for all 34 characters. Tainted Characters Alternate versions unlocked through Home and the Red Key. Completion Marks Hard mode marks, unlock rewards, and Dead God requirements. Character Unlock Guide Step-by-step unlock paths from Isaac to Tainted Jacob.

Bosses & Combat

Pattern guides and strategies for every floor boss, mini-boss, and final boss encounter.

Boss Bestiary Full catalog of bosses organized by floor and chapter. Main Bosses Mom through The Beast — mechanics, HP, and unlock rewards. Mini-Bosses Seven Deadly Sins, Krampus, Rag Man, and other mid-floor threats. Boss Patterns Attack telegraphs and dodge strategies for difficult fights.

Progression & Endings

Track your path from first Mom kill to Dead God and every secret ending.

Secrets List All 640+ secrets, achievements, and unlock conditions. Dead God Guide 100% completion requirements and optimal unlock order. Alternate Path Downpour, Mines, Mausoleum, and Corpse floor walkthrough. Endings Guide All 22 endings and how to trigger each one.

Video Guides

Step-by-step walkthroughs with curated YouTube tutorials for the hardest content.

Unlock The Lost Missing Poster sacrifice room method with video walkthrough. Tainted Characters Ascent path, Red Key, and Cracked Key creation explained. Beat Mother Two-phase boss patterns and recommended items for Corpse II. Beat The Beast Ultra Harbingers and final chase sequence dodge guide.

Game Systems

Core mechanics every Isaac player needs — controls, seeds, challenges, and DLC changes.

Controls Keyboard, controller, and co-op input reference for all platforms. Greed Mode Wave survival, shop mechanics, and Greedier mode unlock. Challenges All 45 challenges, starting items, and unlock rewards. Seeds How seeds work, daily runs, and custom challenge codes.

Interactive Tools

Plan builds and track completion with wiki-integrated utilities.

Synergy Lookup Check how any two items interact before you pick them up. Completion Tracker Track marks, items, secrets, and Dead God progress.

Repentance+ Updates

Latest balance changes, co-op features, and new content from Repentance+.

Repentance+ Guide Patch notes, rebalanced items, and online co-op mechanics. Unlock Order Recommended progression to avoid pool dilution on fresh saves. Trinkets & Cards Consumables, pills, tarot cards, and Cracked Key mechanics. Get Dead God Video guide and checklist for 100% game completion.

Frequently Asked Questions

What DLC do I need for the full Isaac Rebirth experience?

The Binding of Isaac: Repentance includes all previous DLC (Rebirth, Afterbirth, Afterbirth+, and Repentance content). Repentance+ is a free update adding online co-op, balance changes, and additional items. This wiki covers content through Repentance+.

How many items and characters are in Isaac with all DLC?

With Repentance and Repentance+ installed, there are over 719 items, 60+ trinkets, 34 playable characters (17 normal + 17 Tainted), 45 challenges, and 640+ secrets to unlock.

What is Dead God and how do I get it?

Dead God is the Repentance achievement for 100% completion — all hard mode completion marks on every character, all items unlocked, all secrets found, and all challenges beaten. See our Dead God guide and completion tracker for a full checklist.

What is the difference between normal and Tainted characters?

Tainted characters are alternate versions unlocked on Home using the Red Key or Cracked Key. Each has radically different mechanics — Tainted Lost dies in one hit but sees only quality 4 items in shops, Tainted Isaac rerolls items on hit, and Tainted Keeper uses coins as health.

Does this wiki have video guides?

Yes. Every guide page includes a curated YouTube video with verified video IDs covering unlock walkthroughs, boss strategies, and advanced mechanics like angel room manipulation and secret room finding.

Are seeds and daily runs supported for unlocks?

No. Using seeds, daily challenge runs, victory laps, or the debug console disables unlocks for that run. Always play unseeded normal or hard mode runs when working toward character unlocks, completion marks, or Dead God progress.